Johannes Baar und Malte H. Stoffregen: Ein vergessenes
Zeugnis des adrenogenitalen Syndroms
Luigi De Crecchios Beschreibung eines weiblichen
Pseudohermaphroditen (1865)
At present,
the adrenogenital syndrome must surely be reckoned among the most widely known
conditions in endocrine pathology. It may come as a surprise that no
unambiguous cases of adrenogenitalism are on record before the end of the 19th
century. While granting that impressive clinical descriptions may be found in
isolated instances, postmortem findings are either totally missing or were not
recorded in sufficient detail, thus greatly diminishing their value for
retrospective study. This, however, does not apply to a case published by Luigi
de Crecchio, a Naples anatomist, in 1865, of a female
pseudo-hermaphrodite. De Crecchio provides,
for the first time ever, a clear description of a rare pathology, underpinned
by an exemplary postmortem examination, detailed clinical findings, and
biographical data. Based on a complete translation of De CrecchioÕs
article, our study comments on this almost forgotten case history, placing it,
at the same time, in the context of the history of endocrine research.
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